pentobarbital increases toxicity of ifosfamide by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Use Warning/Check. CYP3A4 inducers may boost the metabolism of ifosfamide to its Lively alkylating metabolites.pentobarbital will minimize the extent or result of buprenorphine subdermal implant by influencing hepatic/intestinal enzyme CYP3A4 me… Read More